Table 2.
Significantly upregulated proteins in LPON treated cells
| Accession | Description | HGNC symbol | Peptide count | Confidence score | P-value | Fold change from control |
|---|---|---|---|---|---|---|
| NP_000468.1 | serum albumin preproprotein | ALB | 4 | 173.4 | 0.00 | 11.33 |
| NP_001113.2 | perilipin-2 | PLIN2 | 6 | 387.7 | 0.02 | 10.42 |
| NP_000030.1 | apolipoprotein A-I preproprotein | APOA1 | 2 | 107.5 | 0.02 | 4.08 |
| NP_004453.3 | squalene synthase | FDFT1 | 3 | 159.4 | 0.02 | 3.22 |
| NP_005327.1 | vigilin | HDLBP | 3 | 137.1 | 0.00 | 2.72 |
| NP_005902.1 | S-adenosylmethionine synthase isoform type-2 | MAT2A | 3 | 195.1 | 0.00 | 2.50 |
| NP_001344.2 | aldo-keto reductase family 1 member C1 | AKR1C1 | 4 | 226.8 | 0.00 | 2.41 |
| NP_006627.2 | bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor | MTHFD2 | 2 | 59.6 | 0.02 | 2.39 |
| NP_009224.2 | complement C4-A preproprotein | C4A | 3 | 119.5 | 0.01 | 2.36 |
| NP_006382.1 | importin-7 | IPO7 | 2 | 55.6 | 0.01 | 2.35 |
| NP_036205.1 | T-complex protein 1 subunit epsilon | CCT5 | 4 | 255.7 | 0.00 | 2.30 |
| NP_001407.1 | eukaryotic initiation factor 4A-I | EIF4A1 | 7 | 314.6 | 0.00 | 2.28 |
| NP_000032.1 | apolipoprotein E precursor | APOE | 3 | 152.7 | 0.00 | 2.21 |
| NP_001054.1 | serotransferrin precursor | TF | 6 | 369.9 | 0.02 | 2.18 |
| NP_001165908.1 | retrotransposon-derived protein PEG10 isoform 3 | PEG10 | 2 | 185.2 | 0.01 | 2.13 |
| NP_149351.1 | surfeit locus protein 4 | SURF4 | 2 | 251.8 | 0.01 | 2.13 |
| NP_002769.1 | proactivator polypeptide isoform a preproprotein | PSAP | 4 | 243.4 | 0.00 | 2.09 |
| NP_001952.1 | elongation factor 2 | EEF2 | 13 | 713.0 | 0.00 | 2.07 |
| NP_055121.1 | hypothetical protein LOC51493 | RTCB | 2 | 88.1 | 0.01 | 2.05 |
| NP_001434.1 | fatty acid-binding protein, liver | FABP1 | 4 | 329.0 | 0.02 | 2.01 |
| NP_110379.2 | T-complex protein 1 subunit alpha isoform a | TCP1 | 6 | 392.6 | 0.01 | 2.01 |
| NP_056348.2 | bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) | TKFC | 3 | 169.5 | 0.03 | 2.00 |
| NP_000508.1 | hemoglobin subunit alpha | HBA2 | 2 | 80.4 | 0.01 | 1.99 |
| NP_001159757.1 | T-complex protein 1 subunit eta isoform d | CCT7 | 2 | 194.3 | 0.01 | 1.93 |
| NP_000448.3 | hepatocyte nuclear factor 4-alpha isoform b | HNF4A | 2 | 109.1 | 0.00 | 1.92 |
| NP_001753.1 | T-complex protein 1 subunit zeta isoform a | CCT6A | 5 | 408.0 | 0.01 | 1.92 |
| NP_001650.1 | ADP-ribosylation factor 3 | ARF3 | 3 | 268.5 | 0.00 | 1.90 |
| NP_006364.2 | synaptic vesicle membrane protein VAT-1 homolog | VAT1 | 3 | 174.1 | 0.01 | 1.89 |
| NP_006262.1 | protein S100-A1 | S100A1 | 2 | 215.4 | 0.02 | 1.88 |
| NP_000867.2 | cation-independent mannose-6-phosphate receptor precursor | IGF2R | 3 | 103.2 | 0.02 | 1.88 |
| NP_000383.1 | canalicular multispecific organic anion transporter 1 | ABCC2 | 2 | 104.3 | 0.05 | 1.86 |
| NP_001596.2 | alanyl-tRNA synthetase, cytoplasmic | AARS | 3 | 150.6 | 0.02 | 1.81 |
| NP_002286.2 | 40S ribosomal protein SA | RPSA | 3 | 194.7 | 0.00 | 1.80 |
| NP_001171669.1 | src substrate cortactin isoform c | CTTN | 2 | 62.4 | 0.01 | 1.80 |
| NP_005882.2 | acetyl-CoA acetyltransferase, cytosolic | ACAT2 | 3 | 159.6 | 0.02 | 1.79 |
| NP_001016.1 | 40S ribosomal protein S23 | RPS23 | 2 | 63.0 | 0.00 | 1.76 |
| NP_056174.2 | zinc transporter ZIP14 isoform b | SLC39A14 | 3 | 178.6 | 0.02 | 1.76 |
| NP_003730.4 | aldo-keto reductase family 1 member C3 | AKR1C3 | 3 | 257.7 | 0.02 | 1.73 |
| NP_005971.1 | protein S100-P | S100P | 3 | 164.9 | 0.02 | 1.72 |
| NP_002622.2 | 6-phosphogluconate dehydrogenase, decarboxylating | PGD | 5 | 502.0 | 0.02 | 1.70 |
| NP_005821.2 | 28S ribosomal protein S31, mitochondrial precursor | MRPS31 | 2 | 78.2 | 0.00 | 1.68 |
| NP_001012.1 | 40S ribosomal protein S17 | RPS17 | 5 | 349.2 | 0.01 | 1.68 |
| NP_006422.1 | T-complex protein 1 subunit beta isoform 1 | CCT2 | 5 | 481.5 | 0.03 | 1.68 |
| NP_001018146.1 | NME1-NME2 protein | NME1 | 2 | 105.5 | 0.00 | 1.67 |
| NP_004035.2 | bifunctional purine biosynthesis protein PURH | ATIC | 5 | 247.7 | 0.00 | 1.67 |
| NP_038203.2 | isoleucyl-tRNA synthetase, cytoplasmic | IARS | 2 | 95.1 | 0.02 | 1.65 |
| NP_000775.1 | sterol 26-hydroxylase, mitochondrial precursor | CYP27A1 | 2 | 130.2 | 0.03 | 1.64 |
| NP_006545.1 | metaxin-2 | MTX2 | 2 | 127.2 | 0.00 | 1.64 |
| NP_002203.1 | eukaryotic translation initiation factor 6 isoform a | EIF6 | 3 | 267.9 | 0.00 | 1.64 |
| NP_006089.1 | guanine nucleotide-binding protein subunit beta-2-like 1 | GNB2L1 | 5 | 233.4 | 0.00 | 1.64 |
| NP_001961.1 | eukaryotic translation initiation factor 5A-1 isoform B | EIF5A | 4 | 164.5 | 0.04 | 1.64 |
| NP_631961.1 | TATA-binding protein-associated factor 2 N isoform 1 | TAF15 | 2 | 126.7 | 0.00 | 1.63 |
| NP_001002.1 | 40S ribosomal protein S7 | RPS7 | 3 | 178.1 | 0.00 | 1.62 |
| NP_004387.1 | probable ATP-dependent RNA helicase DDX5 | DDX5 | 3 | 145.9 | 0.02 | 1.61 |
| NP_036555.1 | 60S ribosomal protein L13a | RPL13A | 2 | 72.2 | 0.00 | 1.61 |
| NP_000996.2 | 40S ribosomal protein S3 | RPS3 | 6 | 264.7 | 0.01 | 1.60 |
| NP_006752.1 | 14-3-3 protein epsilon | YWHAE | 3 | 221.6 | 0.00 | 1.60 |
| NP_055205.2 | staphylococcal nuclease domain-containing protein 1 | SND1 | 12 | 567.8 | 0.00 | 1.58 |
| NP_001000.2 | 40S ribosomal protein S5 | RPS5 | 3 | 266.6 | 0.01 | 1.57 |
| NP_005557.1 | L-lactate dehydrogenase A chain isoform 1 | LDHA | 6 | 527.9 | 0.01 | 1.57 |
| NP_005337.2 | heat shock 70 kDa protein 1A/1B | HSPA1B | 8 | 517.1 | 0.01 | 1.57 |
| NP_061819.2 | sialic acid synthase | NANS | 3 | 152.4 | 0.01 | 1.56 |
| NP_001419.1 | alpha-enolase | ENO1 | 14 | 1032.9 | 0.02 | 1.56 |
| NP_733779.1 | S-phase kinase-associated protein 1 isoform b | SKP1 | 3 | 123.7 | 0.01 | 1.55 |
| NP_002385.3 | 4 F2 cell-surface antigen heavy chain isoform c | SLC3A2 | 11 | 680.1 | 0.03 | 1.53 |
| NP_001279.2 | chloride intracellular channel protein 1 | CLIC1 | 4 | 251.6 | 0.00 | 1.53 |
| NP_000792.1 | peptidyl-prolyl cis-trans isomerase FKBP1A isoform a | FKBP1A | 2 | 126.4 | 0.01 | 1.52 |
| NP_001393.1 | elongation factor 1-alpha 1 | EEF1A1 | 16 | 996.3 | 0.00 | 1.52 |
| NP_003893.2 | far upstream element-binding protein 1 | FUBP1 | 2 | 165.0 | 0.00 | 1.52 |
| NP_006392.1 | acidic leucine-rich nuclear phosphoprotein 32 family member B | ANP32B | 2 | 149.5 | 0.02 | 1.50 |
Of the 104 proteins that met the criteria for Category 1, 70 were significantly upregulated with LPON