Table 4.
Summary of enriched GO: Molecular Function terms in LPON treated cells
| Enriched GO: molecular function terms | GO database ID | Log of p-value | Proteins enriched in set |
|---|---|---|---|
| structural constituent of ribosome | GO:0003735 | 10 | MRPS31 RPL13A RPS17 RPS23 |
| RPS3 RPS5 RPS7 RPSA | |||
| poly(A) RNA binding | GO:0044822 | 10 | CCT6A DDX5 EEF1A1 EEF2 EIF4A1 |
| EIF5A ENO1 FUBP1 GNB2L1 HDLBP | |||
| HSPA1B MRPS31 NME1 PEG10 RPL13A | |||
| RPS17 RPS23 RPS3 RPS5 RPS7RPSA | |||
| RTCB SLC3A2 SND1 TAF15 TCP1 YWHAE | |||
| unfolded protein binding | GO:0051082 | 5.5252 | CCT2 CCT5 CCT6A CCT7 HSPA1B TCP1 |
| carboxylic acid binding | GO:0031406 | 5.51 | AARS AKR1C1 ALB FABP1 |
| HNF4A IGF2R MAT2A YWHAE | |||
| organic acid binding | GO:0043177 | 5.4964 | AARS AKR1C1 ALB FABP1 HNF4A |
| IGF2R MAT2A YWHAE | |||
| monocarboxylic acid binding | GO:0033293 | 5.1232 | AKR1C1 ALB FABP1 |
| HNF4A IGF2R | |||
| translation factor activity, RNA binding | GO:0008135 | 4.5729 | EEF1A1 EEF2 EIF4A1 EIF5A EIF6 |
| ketosteroid monooxygenase activity | GO:0047086 | 4.3661 | AKR1C1 AKR1C3 |
| indanol dehydrogenase activity | GO:0047718 | 4.3661 | AKR1C1 AKR1C3 |
| androsterone dehydrogenase activity | GO:0047023 | 4.0662 | AKR1C1 AKR1C3 |
| trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | GO:0047115 | 4.0662 | AKR1C1 AKR1C3 |
| 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity | GO:0047006 | 4.0662 | AKR1C1 AKR1C3 |
| translation elongation factor activity | GO:0003746 | 3.9915 | EEF1A1 EEF2 EIF5A |
Overrepresented GO: Molecular Function terms were identified by ToppCluster. HGNC symbol is used to display proteins enriched under the GO term. p-value cutoff for enriched terms was <0.05 with Bonferroni correction applied to minimize false-positive detection