Fig. 4.

Pathway analysis for different organisms. Thick black or gray arrows – enzyme-dependent subpaths; thin black arrows – enzyme-independent conversions; dashed arrows – other metabolic paths. Ovals – intermediate products; rectangles – enzymes of interest; rounded rectangles – major metabolic paths. a Part of nicotinate and nicotinamide metabolism pathway (KEGG:ko00760). This subpath is present in Anaplasma, Ehrlichia, Francisella, and Coxiella spp. In Francisella and Coxiella – from L-asparate to nicotinate D-ribonucleotide. In Anaplasma and Ehrlichia – from glycerone-P to nicotinate D-ribonucleotide. The path is absent in Bartonella, Rickettsia, and Borrelia spp. b, c Two subpaths of arginine and proline metabolism pathways (KEGG:ko00330). Both are present in Anaplasma, Ehrlichia, Francisella, and Coxiella spp. while absent in Rickettsia, Borrelia, and Bartonella spp., which can complete only the gray arrow path in B. d Part of alanine, aspartate, and glutamate metabolism pathway (KEGG:ko00250). Present in Anaplasma, Ehrlichia, Francisella, and Coxiella spp. while absent in Rickettsia, Borrelia, and Bartonella spp