Table 1.
Characteristics of studies included in this meta-analysis
| Study | Country | Type | Source | Cases | p53 positive rate (%) | IHC Cut off (nuclear positivity) |
|---|---|---|---|---|---|---|
| Madani K, 2010 [12] | Canada | EAC | esophagectomy | 142 | 33.8 | >10 % |
| Casson AG, 1998 [28] | Canada | ESCC/EAC | esophagectomy | 61 | 39 | >10 % |
| Rosa AR, 2003 [29] | Brazil | ESCC | esophagectomy | 47 | 53.2 | >10 % |
| Bahnassy AA, 2005 [30] | Egypt | ESCC/UC | esophagectomy | 50 | 68 | >10 % |
| Egashira A, 2011 [31] | Japan | ESCC | esophagectomy | 94 | 56.4 | >10 % |
| Chanvitan A, 1995 [32] | Canada | ESCC | esophagectomy | 80 | 50 | >10 % |
| Murata, A, 2013 [33] | Japan | ESCC | esophagectomy | 266 | 52 | weak-to-strong |
| Wang DY, 1994 [34] | China | ESCC | esophagectomy | 100 | 65 | >30 % |
| Kato H, 2001 [35] | Japan | ESCC | esophagectomy | 89 | 55.1 | >10 % |
| Flejou JF, 1994 [36] | France | EAC | esophagectomy | 62 | 66 | ND |
| Shimaya K, 1993 [37] | Japan | ESCC | esophagectomy | 105 | 53 | any nuclear positivity |
| Huang K, 2014 [38] | China | ESCC | esophagectomy | 118 | 49.2 | >10 % |
| Lam KY, 1999 [39] | China | ESCC | esophagectomy | 153 | 64.1 | >25 % |
| Chyczewski L, 1999 [40] | Poland | ESCC | esophagectomy | 33 | 45 | >10 % |
| Cavazzola LT, 2009 [41] | Brazil | EAC | esophagectomy | 38 | 52.2 | >10 % |
| Shang L, 2014 [42] | China | ESCC | esophagectomy | 590 | 43 | >10 % |
| Yasuda M, 2000 [27] | Japan | EC | esophagectomy | 35 | 48.5 | dark brown |
| Kuwahara M, 1999 [43] | Japan | EC | esophagectomy | 64 | 48.4 | >10 % |
| Nita ME, 1999 [44] | Brazil | ESCC | esophagectomy | 62 | 50 | >10 % |
| Ikeguchi M, 2000 [45] | Japan | ESCC | esophagectomy | 191 | 44.5 | >50 % |
| Furihata M, 1993 [46] | Japan | ESCC | esophagectomy | 71 | 33.8 | ND |
| Ahn MJ, 2002 [47] | Korea | ESCC/BSCC | esophagectomy | 81 | 51.9 | >10 % |
| Hashimoto N, 1999 [48] | Japan | ESCC | esophagectomy | 73 | 64 | >5 % |
| Makoto O, 2002 [49] | Japan | ESCC | esophagectomy | 96 | 46 | >10 % |
| Hsu PK, 2008 [50] | China | ESCC | esophagectomy | 68 | 63.2 | >25 % |
| Kanamoto A,1999 [51] | Japan | ESCC | esophagectomy | 239 | 48.1 | >10 % |
| Hardwick RH, 1997 [52] | UK | ESCC/EAC | esophagectomy | 78 | 66.7 | >10 % |
| Vijeyasingam R, 1994 [53] | England | ESCC/EAC | esophagectomy | 60 | 68.3 | >5 % |
| Inada S, 1999 [54] | Japan | ESCC | esophagectomy | 40 | 52.5 | >10 % |
| Nakamura T, 1995 [55] | Japan | ESCC | esophagectomy | 61 | 52 | ND |
| Cheng TH, 2009 [56] | China | ESCC | esophagectomy | 119 | 51.3 | >10 % |
| Yao W, 2014 [57] | China | ESCC | esophagectomy or endoscopy | 136 | 41.9 | weak-to-strong |
| Takeno S, 2002 [58] | Germany | ESCC | esophagectomy | 71 | 36.6 | >10 % |
| Xu XL, 2014 [59] | China | ESCC | esophagectomy | 775 | 35.9 | >10 % |
| Takahashi Y, 2006 [60] | Japan | ESCC | esophagectomy | 180 | 61.7 | >10 % |
| Goukon Y, 1994 [61] | Japan | ESCC | esophagectomy | 49 | 59 | any nuclear positivity |
UC undifferentiated carcinoma, BSCC basaloid squamous cell carcinoma, ND not documented