Table 3.
Subgroup meta-analyses of p53 expression and survival according to histological type, continent and cut-off value
| Subgroup | N | Cases | Pooled RR (95 % CI) | P value | Analytical model | Heterogeneity | |
|---|---|---|---|---|---|---|---|
| I2 (%) | P value | ||||||
| Histological type | |||||||
| ESCC only | 23 | 3454 | 1.32 (1.10–1.57) | 0.002 | REM | 70 | < 0.00001 |
| EAC only | 3 | 242 | 1.61 (1.05–2.47) | 0.03 | FEM | 16 | 0.3 |
| Continent | |||||||
| Asia | 22 | 3372 | 1.24 (1.04–1.48) | 0.02 | REM | 72 | < 0.00001 |
| Europe and America | 9 | 640 | 1.54 (1.22–1.94) | 0.0003 | FEM | 30 | 0.18 |
| Cut-off value | |||||||
| 10 % | 20 | 2949 | 1.18 (0.96–1.45) | 0.12 | REM | 71 | < 0.00001 |
| None-10 % | 12 | 1113 | 1.56 (1.35–1.81) | < 0.00001 | FEM | 44 | 0.05 |
N number of studies, FEM fixed-effect model, REM random-effect model