Table 1.
Characteristics of all patients
| Patients with RILD | Patients without RILD | |
|---|---|---|
| Variables | N = 13 | N = 23 |
| Gender | ||
| Male | 11 | 19 |
| Female | 2 | 4 |
| Median age at reirradiation | 64 | 71 |
| (range, 32 to 77) | (range, 33 to 89) | |
| TNM stage (AJCC 7th edition) | ||
| T1N0M0 | 2 | 4 |
| T2N0M0 | 1 | 7 |
| T3N0M0 | 5 | 9 |
| T4N1M0 | 1 | 0 |
| T3N0M1 | 4 | 3 |
| Previous local treatment | ||
| Surgery | 1 | 2 |
| TAE/TACE | 7 | 12 |
| RFA/Cryo | 2 | 5 |
| Category of previous hepatitis | ||
| Hepatitis B infection | 6 | 10 |
| Hepatitis C infection | 2 | 6 |
| non-HBV and non-HCV induced | 5 | 7 |
| CTP scores before the 2nd RT | 6.3 ± 1.1 | 5.2 ± 0.5 |
| Interval between 2 courses (months) abutting score for two PTV | 8.1 ± 8.1 | 12.6 ± 12.2 |
| 0 | 4 | 5 |
| 1 | 2 | 9 |
| 2 | 7 | 9 |
| 1st RT parameters | ||
| Mean prescribed dose (EQD2, Gy) | 49.5 ± 8.2 | 52.5 ± 5.7 |
| Mean CTV (cm3) | 392.9 ± 407.0 | 345.2 ± 565.0 |
| Mean PTV (cm3) | 257.9 ± 207.8 | 314.4 ± 480.7 |
| Mean normal liver dose (EQD2, Gy) | 20.8 ± 11.3 | 20.1 ± 8.2 |
| Mean normal liver volume (cm3) | 1255.5 ± 569.4 | 926.5 ± 242.4 |
| 2nd RT parameters | ||
| Mean prescribed dose (EQD2, Gy) | 32.9 ± 14.5 | 40.6 ± 12.8 |
| Mean CTV (cm3) | 139.1 ± 150.2 | 211.3 ± 343.1 |
| Mean PTV (cm3) | 257.9 ± 207.8 | 314.4 ± 480.7 |
| Mean normal liver dose (EQD2, Gy) | 12.3 ± 6.6 | 10.2 ± 5.5 |
| Mean normal liver volume (cm3) | 1173.4 ± 622.2 | 992.5 ± 196.1 |
| Mean cumulative prescribed dose (EQD2, Gy) | 80.9 ± 17.8 | 94.4 ± 13.9 |
| Mean cumulative normal liver dose (EQD2, Gy) | 32.5 ± 15.1 | 30.5 ± 9.6 |
Abbreviation: RILD radiation-induced liver disease, TNM stage was evaluated before reirradiation; TAE transarterial embolization, TACE transarterial chemo-embolization, RFA radiofrequency ablation, Cryo cryotherapy, RT radiotherapy, CTV clinical tumor volume, PTV planning target volume, EQD2 biologically equivalent doses calculated in 2Gy
Note: abutting score: if reirradiation applied to a PTV separated from the previous PTV because the tumors were located at different segments, this situation was defined as out-field reirradiation (score = 0). For patients receiving reirradiation at the same or adjacent segment, the 2nd PTVs might be partially included in the previous PTV (score 1), or completely included (score 2)