Table 3.
Risk factors associated with lethal RILD after reirradiation
| Variables | Lethal RILD (+) | Lethal RILD (−) | Univariate | Multivariate | ||
|---|---|---|---|---|---|---|
| p value | p value | OR | 95 % CI | |||
| Total number | 9 | 27 | ||||
| Liver function before 2nd RT | ||||||
| Total bilirubin ≧2.0 mg/dL | 4 | 0 | 0.002 | |||
| Albumin ≦3.5 g/dL | 6 | 6 | 0.001 | |||
| Presence of ascites | 3 | 1 | 0.014 | |||
| INR ≧1.71 | 0 | 0 | ||||
| CTP score ≧6 | 8 | 6 | <0.001 | 0.005 | 72.5554 | 3.650 ~ 1442.252 |
| Presence of PVTT | 7 | 6 | 0.003 | |||
| AST/ALT ≧3x of upper normal limit | 4 | 2 | 0.121 | |||
| Hepatitis | ||||||
| Hepatitis B infection | 5 | 11 | 0.439 | |||
| Hepatitis C infection | 1 | 7 | 0.355 | |||
| RT parameters of 2nd RT | ||||||
| Mean CTV (cm3) | 195.2 ± 166.9 | 186.4 ± 331.7 | 0.806 | |||
| Mean PTV (cm3) | 315.5 ± 224.5 | 285.7 ± 447.7 | 0.890 | |||
| Mean normal liver dose (EQD2, Gy8) | 9.7 ± 6.8 | 11.3 ± 5.2 | 0.019 | |||
| Mean normal liver volume (cm3) | 1305.8 ± 687.6 | 975.2 ± 210.5 | 0.078 | |||
| Interval between 2 courses (month) | 6.0 ± 8.5 | 12.7 ± 11.4 | 0.119 | |||
| Mean cumulative normal liver dose (EQD2, Gy8) | 27.9 ± 12.5 | 32.2 ± 11.5 | 0.221 | |||
| Mean cumulative prescribed dose (EQD2, Gy15) | 75.0 ± 12.7 | 92.1 ± 14.7 | 0.005 | |||
| Abutting score for two PTV | 1.4 ± 0.8 | 1.1 ± 0.8 | 0.824 | |||
Abbreviation as Table 2