Table 4.
Pretreatment liver function before the 1st course of RT and the association with RILD after reirradiation
| Variables | RILD (+) | RILD (−) | Univariate |
|---|---|---|---|
| p value | |||
| Total number | 13 | 23 | |
| Liver function before 1st RT | |||
| Total bilirubin ≧2.0 mg/dL | 0 | 0 | |
| Albumin ≦3.5 g/dL | 5 | 3 | 0.54 |
| Ascites | 0 | 0 | |
| INR ≧1.71 | 0 | 0 | |
| CTP score ≧6 | 4 | 2 | 0.77 |
| AST/ALT ≧3x of upper normal limit | 3 | 2 | 0.38 |
| Presence of PVTT | 5 | 3 | 0.75 |
| RT parameters | |||
| Mean PTV of the 1st RT (cm3) | 605.7 ± 551.5 | 410.6 ± 667.6 | 0.41 |
| Mean normal liver dose of 1st RT (EQD2, Gy8) | 20.8 ± 12.0 | 21.3 ± 8.7 | 0.87 |
| Mean normal liver volume of 1st RT (cm3) | 1255.5 ± 592.4 | 1055.3 ± 274.3 | 0.17 |
Abbreviation: RILD radiation-induced liver disease, OR odds ratio, CI confidence interval, CTP Child-Turcotte-Pugh, PVTT portal vein tumor thrombosis, AST aspartate aminotransferase, ALT alanine aminotransferase, CTV clinical tumor volume, NS no significance, EQD2 biologically equivalent doses calculated in 2Gy