Table 1.
Summary Vif-mediated A3 degradation
| Feline A3a | Degradation by Vif | Rescue of infection by Vifb | |||||
|---|---|---|---|---|---|---|---|
| FIV | HIV-1 | HIV-2 | SIVmac/smm | FIV | HIV-2 | SIVmac | |
| A3Z2 | ++ | − | − | − | ND | − | − |
| A3Z2.DH-YN | − | ND | ND | ND | ND | ND | ND |
| A3Z3 | ++ | − | − | − | ++ | − | − |
| A3Z3.A65I | ± | ND | ND | ND | ± | ND | ND |
| A3Z3.LI-AA | ± | ND | ND | ND | ± | ND | ND |
| A3Z3.A65I + LI-AA | − | ND | ND | ND | − | ND | ND |
| A3Z2Z3 | ++ | − | ++ | ++ | ++ | ++ | ++ |
| A3Z2Z3-M | − | ND | ++ | ++ | − | ND | ND |
| A3Z2Z3ΔLinker | ++ | − | ± | ± | ND | ND | ND |
Degradation of A3 by Vif: ++, mostly degraded; ±, partial degradation with high amount of Vif; −, no degradation
Rescue of infection by Vif: ++, complete rescue; ±, partial rescue; −, no rescue
ND not done
aFeline A3: A3s from domestic cat Felis catus
bExperiments to rescue the infection were not done with HIV-1 and SIVsmm