Figure 1.
ArhGAP11A and RacGAP1 are highly expressed in BLBC. A-B, the expression of Rho GEF, GAP, GTPase, and GDI genes in basal-like breast tumors is shown relative to their expression in (A) normal or (B) luminal A tumors, as determined from TCGA RNA-Seq data. The 24 genes with the highest relative expression in the basal-like subtype are shown. C, TCGA RNA-Seq data showing row median centered expression levels of ARHGAP11A and RACGAP1 mRNA in human breast tumors of different subtype. D, blot analyses for ArhGAP11A and RacGAP1 expression in human breast cancer cell lines of different subtypes. Actin expression was determined to verify equivalent loading of total protein.