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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Cancer Res. 2016 May 23;76(13):3826–3837. doi: 10.1158/0008-5472.CAN-15-2923

Figure 3.

Figure 3

RacGAP1-knockdown results in cytokinesis failure. A, representative fluorescent images showing actin (green) and Hoechst (blue) staining of SUM149 cells with or without knockdown of ArhGAP11A or RacGAP1. Scale bar = 20 μm. Arrowheads in merged images indicate binucleated cells. B-C, quantification of the percentage of bi/multinucleated (B) SUM149 or (C) HCC1937 cells with or without knockdown of ArhGAP11A or RacGAP1 (n = three independent experiments in each case ±SEM, ≥ 108 total cells/condition/experiment). Statistical significance, relative to the NS control, was determined by one-way ANOVA with Dunnett's post-hoc test.