(A) Oxygen consumption rate (OCR) measured immediately before and after addition of Met analogs, and (B) OCR measured in intact cells after 24 h pre-treatment. The indices of mitochondrial function were determined by injecting oligomycin (O, 1 μg/ml) to inhibit ATP synthase, 2,4-dinitrophenol (D, 50 μM) to uncouple the mitochondria, and rotenone (R, 1 μM) and antimycin A (A, 10 μM) as inhibitors of complex I and complex III, respectively. Dashed vertical linesindicate the time of injection of the compounds.