|
| ||
| Effects of CDKN2A/B-related proteins on metabolic tissues | ||
| Tissue | Protein | Effects |
|
| ||
| Islets | p16INK4A | Restricts beta cell proliferation in ageing, restricts beta cell regeneration, mediates overnutrition-related senescence, reduces insulin secretory function |
| CDK4 | Required for postnatal beta cell mass expansion | |
| Cyclin D1, D2 | Required for postnatal beta cell mass expansion | |
| Adipose | p15INK4B | Inhibits adipocyte differentiation |
| p16INK4A | Modulates adipose macrophage activation and polarisation | |
| CDK4 | Promotes adipocyte differentiation | |
| Liver | p16INK4A | Restrains hepatic gluconeogenesis |
| Cyclin D1/CDK4 | Regulates fasted–fed transition | |
| Muscle | CDK4 | Impacts mitochondrial oxidative metabolism via E2F1 |
|
| ||
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