Table 4.
Risk of endometrial cancer comparing the 5th to the 1st quintile for parent estrogens across categories of BMI, age, and years of oral contraceptive use.
| BMI | OR1 | (95% CI) | p-trend | p-intx | Age | OR1 | (95% CI) | p-trend | p-intx | Years of OC Use | OR1 | (95% CI) | p-trend | p-intx | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parent estrogens | |||||||||||||||
| Estrone | |||||||||||||||
| <25 | 3.62 | (1.00–13.11) | 0.02 | 0.41 | <60 | 2.44 | (0.63–9.44) | 0.25 | 0.36 | Never | 2.12 | (1.00–4.49) | 0.01 | 0.10 | |
| 25–29.9 | 1.08 | (0.33–3.54) | 0.29 | 60–69 | 2.60 | (1.03–6.54) | 0.003 | <5 yrs | 14.52 | (2.25–93.77) | 0.01 | ||||
| ≥30 | 8.06 | (1.82–35.77) | 0.004 | ≥70 | 10.60 | (2.80–40.10) | 0.001 | ≥5 yrs | 15.15 | (0.79–292.14) | 0.02 | ||||
| Unconjugated Estrone | |||||||||||||||
| <25 | 3.35 | (1.16–9.69) | 0.01 | 0.50 | <60 | 2.90 | (0.81–10.42) | 0.17 | 0.23 | Never | 1.71 | (0.85–3.44) | 0.04 | 0.12 | |
| 25–29.9 | 1.16 | (0.39–3.43) | 0.48 | 60–69 | 2.46 | (1.02–5.92) | 0.05 | <5 yrs | 29.90 | (4.08–219.16) | 0.003 | ||||
| ≥30 | 6.00 | (1.51–23.94) | 0.02 | ≥70 | 4.45 | (1.29–15.29) | 0.001 | ≥5 yrs | 7.12 | (0.50–100.97) | 0.008 | ||||
| Conjugated Estrone | |||||||||||||||
| <25 | 3.43 | (1.05–11.26) | 0.03 | 0.53 | <60 | 2.53 | (0.67–9.56) | 0.22 | 0.10 | Never | 2.01 | (0.95–4.26) | 0.04 | 0.15 | |
| 25–29.9 | 1.19 | (0.35–4.02) | 0.32 | 60–69 | 2.45 | (0.99–6.09) | 0.009 | <5 yrs | 10.60 | (2.12–53.14) | 0.005 | ||||
| ≥30 | 7.89 | (2.02–30.77) | 0.01 | ≥70 | 8.10 | (2.23–29.46) | 0.003 | ≥5 yrs | 7.43 | (0.39–142.68) | 0.06 | ||||
| Estradiol | |||||||||||||||
| <25 | 0.88 | (0.25–3.03) | 0.86 | 0.30 | <60 | 2.76 | (0.70–10.94) | 0.59 | 0.08 | Never | 1.22 | (0.57–2.60) | 0.33 | 0.36 | |
| 25–29.9 | 0.52 | (0.16–1.67) | 0.37 | 60–69 | 0.92 | (0.33–2.52) | 0.76 | <5 yrs | 3.75 | (0.54–26.15) | 0.69 | ||||
| ≥30 | 6.56 | (1.06–40.51) | 0.05 | ≥70 | 1.53 | (0.48–4.87) | 0.51 | ≥5 yrs | 6.23 | (0.45–85.47) | 0.52 | ||||
| Unconjugated Estradiol | |||||||||||||||
| <25 | 7.84 | (2.1–29.22) | 0.01 | 0.48 | <60 | 8.74 | (1.47–51.92) | 0.17 | 0.50 | Never | 4.19 | (1.84–9.56) | 0.01 | 0.25 | |
| 25–29.9 | 2.39 | (0.64–8.99) | 0.06 | 60–69 | 4.82 | (1.60–14.52) | 0.04 | <5 yrs | ** | 0.002 | |||||
| ≥30 | 6.60 | (1.02–42.75) | 0.05 | ≥70 | 12.61 | (3.17–50.13) | 0.001 | ≥5 yrs | 4.62 | (0.29–74.7) | 0.05 | ||||
| Conjugated Estradiol | |||||||||||||||
| <25 | 0.79 | (0.23–2.74) | 0.79 | 0.16 | <60 | 1.85 | (0.55–6.25) | 0.64 | 0.24 | Never | 0.78 | (0.37–1.66) | 0.66 | 0.10 | |
| 25–29.9 | 0.29 | (0.09–0.94) | 0.08 | 60–69 | 0.68 | (0.25–1.83) | 0.41 | <5 yrs | 1.26 | (0.22–7.16) | 0.99 | ||||
| ≥30 | 5.31 | (0.87–32.4) | 0.21 | ≥70 | 0.68 | (0.20–2.29) | 0.86 | ≥5 yrs | 7.41 | (0.54–100.96) | 0.19 | ||||
1
OR (quintile 5 vs. quintile 1) from model adjusted for matching factors [age at baseline, calendar year of blood draw, race/ethnicity, and recency of MHT use (never, ≤1/>1 year)] and education, cigarette smoking status, age at menarche, gravidity, age at menopause, and previous tubal ligation. Additional adjustment was made for BMI and years of oral contraceptive use, if relevant.
**
Could not be estimated; too few cases in reference category