Table 3.
Geometric means (95% confidence intervals) of baseline urinary mercapturic acid metabolites of benzene, acrolein and crotonaldehyde, prostaglandin E2 metabolite (PGEM), and 8-iso-prostaglandin F2α (8-iso-PGF2α) in smokers separated by glutathione S-transferase (GST) M1 and T1 genotypes, The PEITC Intervention Study 2008–2013
| GST genotype | Na | Benzene SPMA (pmol/mg Cr)b | Acrolein HPMA (nmol/mg Cr)b | Crotonaldehye HMPMA (nmol/mg Cr)b | PGEM (pmol/mg Cr)b | 8-iso-PGF2α (pmol/mg Cr)b |
|---|---|---|---|---|---|---|
| GSTM1 | ||||||
| Null | 36 | 1.72 (1.22–2.40) | 7.12 (5.98–8.48) | 5.16 (4.22–6.28) | 41.18 (34.22–49.58) | 0.88 (0.76–1.02) |
| Present | 45 | 3.10 (2.28–4.20) | 6.28 (5.36–7.36) | 4.28 (3.58–5.12) | 46.42 (39.26–54.88) | 0.82 (0.70–0.94) |
| P | 0.014 | 0.309 | 0.186 | 0.357 | 0.442 | |
| GSTT1 | ||||||
| Null | 19 | 0.80 (0.52–1.18) | 7.22 (5.64–9.22) | 5.26 (3.98–6.94) | 45.32 (34.90–58.86) | 0.78 (0.64–0.98) |
| Present | 62 | 3.34 (2.68–4.18) | 6.48 (5.66–7.40) | 4.48 (3.86–5.22) | 43.58 (37.78–50.26) | 0.86 (0.76–0.96) |
| P | <0.001 | 0.459 | 0.338 | 0.799 | 0.495 | |
| GSTM1 & GSTT1 | ||||||
| Both null | 12 | 0.44 (0.28–0.74) | 8.58 (6.26–11.74) | 5.76 (4.02–8.26) | 43.18 (30.76–60.62) | 0.86 (0.64–1.14) |
| One present | 31 | 2.84 (2.12–3.82) | 6.28 (5.22–7.58) | 4.82 (3.88–5.96) | 42.06 (34.38–51.48) | 0.84 (0.72–1.00) |
| Both present | 38 | 3.56 (2.74–4.66) | 6.40 (5.40–7.58) | 4.22 (3.48–5.12) | 45.88 (38.20–55.12) | 0.84 (0.72–0.98) |
| P for trend | <0.001 | 0.244 | 0.130 | 0.617 | 0.891 | |
a
One subject who did not provide urine sample at baseline was excluded from all analyses.
b
All geometric means were adjusted for age and gender.