. Author manuscript; available in PMC: 2017 Jul 1.

Published in final edited form as: Vet Ophthalmol. 2016 Apr 19;19(Suppl 1):119–130. doi: 10.1111/vop.12375

Table 2.

Maximum (C_max) and minimum plasma and tear penciclovir concentrations and time to plasma and tear C_max in cats administered a variety of famciclovir doses at various dose frequencies.

Famciclovir dose	Dose frequency	Plasma [penciclovir] (ng/mL)		Plasma penciclovir T_max (h)	Tear [penciclovir] (ng/mL)		Tear penciclovir T_max (h)
Famciclovir dose	Dose frequency	C_max	C_ss(min)	Plasma penciclovir T_max (h)	C_max	C_ss(min)	Tear penciclovir T_max (h)
9-18 mg/kg[54]	BID	330	64	5.3	ND	ND	ND
9-18 mg/kg[54]	TID	680	180	3.8	ND	ND	ND
30 mg/kg[50]	BID	2010	345	1.3	305	65	4.7
30 mg/kg[50]	TID	1755	570	1.7	395	160	2.0
40 mg/kg[50]	BID	1945	445	2.3	375	55	3.3
40 mg/kg[50]	TID	2210	790	2.5	750	150	2.6
90 mg/kg[50]	BID	2720	630	2.7	680	200	2.3
90 mg/kg[50]	TID	2015	905	2.7	555	275	3.0

Abbreviations: BID: twice daily; C_max: Maximum observed drug concentration; C_ss(min): minimum observed drug concentration during the dosing interval at steady state; ND: Not done; TID; thrice daily; T_max: Time to C_max.