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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Neurobiol Dis. 2016 May 1;93:226–242. doi: 10.1016/j.nbd.2016.04.010

Figure 1. The expression of PAR1, thrombin and neurosin (Klk6) are elevated in response to contusion-compression SCI.

Figure 1

Histograms show transcriptional changes in RNA encoding PAR1, thrombin or neurosin in the spinal cord of uninjured control (C) PAR1+/+ mice, or at the level of the injury epicenter (E), above (A), or below (B), at 7 and 30 dpi (A – F). Transcriptional changes after injury are expressed as a percent of the uninjured genotype control and these data were used for statistical comparisons. Injury induced elevations in thrombin (C, D) or neurosin (E, F) were reduced or absent in mice lacking the PAR1 gene. Expression levels of thrombin and neurosin in uninjured PAR1−/− spinal cord are expressed as a percent of that seen in PAR1+/+ mice and no significant differences were observed. (*P < 0.03; **P = 0.009, ***P ≤ 0.001 NK; ND, not detected).