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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Neurobiol Dis. 2016 May 1;93:226–242. doi: 10.1016/j.nbd.2016.04.010

Figure 2. The expression of PAR1, thrombin and neurosin increase differentially in astrocytes and microglia/monocytes in response to SCI.

Figure 2

Photomicrographs show co-localization of PAR1 (A, B), Thrombin (C, D) and Neurosin (E, F) with GFAP+ astrocytes or IsoB+ microglia/monocytes, in the uninjured spinal cord (Control) or within the injury epicenter at 30 dpi. Immunoreactivity for PAR1, thrombin, neurosin, GFAP and IsoB were all increased in the SCI epicenter at 30 dpi. PAR1, thrombin and neurosin were each localized to astrocytes in the uninjured spinal cord with an increase in co-colonization after injury. IsoB+ microglia/monocytes were also co-labeled for PAR1 and neurosin but not thrombin. Examples of double labeled cells in each case are shown at arrowheads (Scale bar = 20 um).