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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Neurobiol Dis. 2016 May 1;93:226–242. doi: 10.1016/j.nbd.2016.04.010

Figure 3. PAR1 gene deficient mice show improved locomotor recovery after experimental contusion-compression SCI.

Figure 3

(A) Basso Mouse Scale (BMS) scores evaluated in PAR1+/+ and PAR1−/− mice from 0 to 31 d after SCI, demonstrate significant improvements in over-ground locomotion. Significantly higher levels of recovery on the BMS were observed in PAR1−/− mice at 14 dpi (P = 0.005) and at each time point thereafter (P < 0.001). (B) BMS subscores were significantly higher in PAR1−/− compared to PAR1+/+ mice starting on 14 dpi (P = 0.008) and continuing through the last time point examined (P < 0.001). (C, D) Improvements in stepping accuracy in the easy and hard rung spacing ladder walk tests were observed at 31 dpi (P ≤ 0.01). Improvements in ladder walk accuracy were also observed at 22 dpi in PAR2−/− relative to PAR2+/+ mice in the hard set up (P = 0.04). (E) PAR2−/− mice showed significantly better motor strength in the incline plane test at 14, 21 and 30 dpi relative to that observed in PAR2+/+ mice (P ≤ 0.02). Data shown represents the mean and standard error of results obtained across two independent experiments, PAR1+/+, n=16; PAR1−/− n=9. (Two Way Repeated Measures ANOVA, NK *P ≤ 0.04, **P ≤ 0.008, ***P < 0.001).