Fig. 5. Effect of BZL on hepatic Mrp2 expression in wild type and Nrf2−/− mice.
Hepatic Mrp2 expression was quantified at the mRNA level in wild type and Nrf2 knock out control (vehicle exposed) and BZL treated mice (200 mg/kg b.w./ day, 3 consecutive days, i.p.) by real time PCR. Expression of Mrp2 (Abcc2) mRNA was normalized to β-actin mRNA. The data (mean ± S.D., n = 3) are expressed as percentage of the mRNA in the corresponding control (C) mice of each genotype. * different from the corresponding C, p<0.05.