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. 2016 Jun 18;7(7):501–515. doi: 10.1007/s13238-016-0284-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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S228P aggregates could be redissolved by lanosterol but not cholesterol in a concentration-dependent manner. (A) Representative confocal images of cells expressing S228P treated with, 20 µmol/L cholesterol or lanosterol. For clarity, the staining of the nucleus was not shown. (B) Quantitative analysis of the percentage of cells with protein aggregates. The cells were transfected by plasmids containing the WT and mutated βB1 genes and cultivated for 24 h to allow the formation of crystallin aggregates. Then the cells were treated by 1% DMSO, cholesterol in 1% DMSO or lanosterol 1% DMSO