Fig. 1.

CNV-Seq chromosome plots of unbalanced embryos. a Unbalanced derivatives of t(11;16)(q13;q12). The two terminal imbalances were detected as an 80.1-Mb 11q deletion and a 41.5-Mb 16q duplication, with mean copy numbers of 1.0 and 3.0, respectively. The control chromosome 21 has a mean copy number of 2.0. b Unbalanced derivatives of t(10;12)(q22;q14). The two terminal imbalances were detected as an 87.5-Mb 10p deletion and a 70.2-Mb 12q duplication, with mean copy numbers of 1.0 and 3.0, respectively. An incidental aneuploidy involving mosaic chromosome 21 with a mean copy number of 1.8 was detected in the same embryo