Table 3.
Evaluations at 48 h in peripheral blood of mice. Averages of early and late apoptotic and necrotic cells per group.
Group | Dose (mg/kg) | N | ± SD | ||
---|---|---|---|---|---|
Early apoptotic | Late apoptotic | Necrotic | |||
Control (water) | 0 | 5 | 12.6 ± 1.7 | 1.2 ± 0.4 | 0.8 ± 0.4 |
Control (corn oil) | 0 | 5 | 10.6 ± 2.1 | 1.0 ± 0.0 | 0.6 ± 0.5 |
AA | 100 | 5 | 1.0 ± 0.7a | 33.4 ± 2.5a | 0.2 ± 0.4 |
α-TOH | 20 | 5 | 6.8 ± 3.2 | 37.8 ± 4.1b | 0.2 ± 0.4 |
V2O5 | 40 | 5 | 21.2 ± 5.6a,b | 40.8 ± 5.4a,b | 2.4 ± 1.3a,b,c,d |
AA + V2O5 | 100 + 40 | 5 | 23.8 ± 2.4a | 34.2 ± 1.9a | 0.8 ± 0.5 |
α-TOH + V2O5 | 20 + 40 | 5 | 25.0 ± 3.5b | 41.6 ± 4.6b | 0.6 ± 0.5 |
a p < 0.05 versus control (water); b p < 0.05 versus control (corn oil); c p < 0.05 versus AA + V2O5; d p < 0.05 versus α-TOH + V2O5. Nonviable cells include apoptotic and necrotic cells. 200 nucleated cells were evaluated in each mouse (5 mice per group).