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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Curr Pharm Des. 2016;22(17):2481–2490. doi: 10.2174/1381612822666160307151409

Figure 1.

Figure 1

Schematic diagram for cell targeted delivery of therapeutic agents carried by a nanoparticle. The process is comprised of three sequential steps: (i) nanoparticle binding to target cells via multivalent receptor–ligand interactions, (ii) intracellular uptake of the nanoparticle via receptor-mediated endocytosis, and (iii) intracellular drug release or action [1].

Abbrevation: AuNP: Gold nanoparticle;IONP: Iron Oxide nanoparticle; QD: Quantum dots; FA:folic acid; MTX: methotrexate; RF: riboflavin; EGF: epidermal growth factor; RGD: Arg-Gly-Asp; FAR: folate receptor; RFR:riboflavin receptor; EGFR: epidermal growth factor receptor; PSMA: prostate-specific membrane antigen