Table 2.

Gavage: Summary of results for the emesis end-point. Various doses of trichothecenes were administered to the mink animal model using the gavage method. N=4 for Type A and N=6 for Type B trichothecenes. The data presented were generated by studies conducted by Wu et al. (2012a) and reported in an earlier publication. HT-2 (HT-2 toxin), T-2 (T-2 toxin), DON (deoxynivalenol), 3-ADON (3-acetyldeoxynivalenol), 15-ADON (15-acetyldeoxynivalenol), NIV (nivalenol), FX (Fusarenon X).

Toxin	Doses (mg/kg bw)	Incidence	Latency (min)	Emesis duration (min)	Number of emetic events
					Retching	Vomiting	Total
HT-2	0	0/4
	0.005	0/4
	0.05	3/4	27 ± 7.1	49.7 ± 11.2	60.3 ± 24.4	7.3 ± 2.9	67.5 ± 27.3
	0.25	4/4	21.6 ± 3.8	120.6 ± 21.2	157.3 ± 24.2	17.8 ± 2.4	175 ± 26.4
	0.5	4/4	19.1 ± 1.8	200.6 ± 18.1	222.3 ± 28.5	23 ± 3.2	245.3 ± 31.2
T-2	0	0/4
	0.005	0/4
	0.05	3/4	22.5 ± 2.6	52.3± 15.4	66.3±22.6	8±3.1	74.3 ± 25.5
	0.25	4/4	19.5 ± 3.3	108 ± 11.1	130 ± 16.9	17.3 ± 1.3	147.3 ± 18.1
	0.5	4/4	13.1 ± 3.2	170.9 ± 22.1	191.3 ± 50.4	21 ± 2.6	212.3 ± 52.7
3-ADON	0	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.05	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.25	1/6	62 ± 0	1 ± 0	2 ± 2	1 ± 1	3 ± 3
	0.5	5/6	53 ± 9	12 ± 9	16 ± 8	4 ± 1	20 ± 9
	1	6/6	19 ± 4	44 ± 9	65 ± 11	14 ± 2	79 ± 13
15-ADON	0	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.01	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.1	5/6	20 ± 4	1 ± 1	9 ± 3	2 ± 1	11 ± 4
	0.5	6/6	18 ± 3	3 ± 1	24 ± 5	6 ± 1	30 ± 5
	1	6/6	17 ± 4	14 ± 7	26 ± 5	6 ± 1	32 ± 6
DON	0	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.01	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.05	5/6	15 ± 2	1 ± 1	12 ± 4	3 ± 1	15 ± 5
	0.25	6/6	17 ± 2	6 ± 1	44 ± 13	8 ± 1	52 ± 15
	0.5	6/6	11 ± 2	14 ± 3	62 ± 9	9 ± 1	71 ± 10
FX	0	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.01	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.05	4/6	23 ± 2	13 ± 10	8 ± 3	2 ± 1	10 ± 4
	0.25	6/6	36 ± 10	34 ± 11	38 ± 5	11 ± 2	49 ± 7
	0.5	6/6	15 ± 3	63 ± 21	45 ± 4	13 ± 2	58 ± 4
NIV	0	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.05	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.1	0/6	-	-	0 ± 0	0 ± 0	0 ± 0
	0.25	4/6	31 ± 3	15 ± 10	21 ± 14	4 ± 2	25 ± 16
	0.5	6/6	29 ± 4	32 ± 10	55 ± 14	9 ± 2	64 ± 15