Fig. 4. CPT reversed TNF-α-induced LOX-1 expression in HUVECs.

Cells were incubated with TNF-α (10 ng/mL) for 24 h with or without CPT pretreatment for 1 h, the protein expression of LOX-1 were determined (A). Cells were pretreated with PD98059 (50 µM) or BAY11-7802(50 µM) for 1 h and then incubated with TNF-α (10 ng/mL) for 24 h, the protein expression of LOX-1 was determined (B). CPT, cryptotanshinone; ^*p<0.05 and ^**p<0.01 vs. TNF-α treated group.