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. 2016 Jun 23;20(4):407–414. doi: 10.4196/kjpp.2016.20.4.407

Fig. 4. Effect of spinal serotonergic receptor subtypes antagonist on EA-induced anti-allodynia.

Fig. 4

The behavioral tests for cold allodynia were performed before the intrathecal injection of antagonists and after EA treatment in four groups: (A) DMSO (n=4), (B) NAN-190 (n=6), (C) ketanserin (n=8), and (D) MDL-72222 (n=6). MDL-72222 (5-HT3 receptor antagonist) completely blocked the analgesic effect of EA; however, DMSO, NAN-190 (5-HT1A receptor antagonist), and ketanserin (5-HT2A receptor antagonist) did not alter the anti-allodynic effect of EA. Data are presented as mean±SEM.; ***p<0.001, **p<0.01, *p<0.05; by paired t-test.