Table 3.
UGT1A1 gene polymorphism and toxicities (≥ grade 3)
| Side effect | *6/*6 | *28/*6 | *28/− | *6/− | −/− | P | |
|---|---|---|---|---|---|---|---|
| *28 | *6 | ||||||
| Febrile neutropenia | 0 | 0 | 2 | 6 | 3 | 0.589 | 0.230 |
| (%) | (0) | (0) | (29) | (35) | (14) | — | — |
| Leukopenia | 0 | 0 | 6 | 9 | 7 | 0.049* | 0.486 |
| (%) | (0) | (0) | (86) | (53) | (32) | — | — |
| Neutropenia | 1 | 0 | 6 | 9 | 8 | 0.039* | 0.465 |
| (%) | (100) | (0) | (86) | (53) | (36) | — | — |
| Anemia | 0 | 0 | 0 | 4 | 2 | 1 | 0.390 |
| (%) | (0) | (0) | (0) | (24) | (9) | — | — |
| Thrombocytopenia | 0 | 0 | 0 | 2 | 3 | 0.545 | 1 |
| (%) | (0) | (0) | (0) | (12) | (14) | — | — |
| Diarrhea | 1 | 0 | 1 | 2 | 1 | 0.469 | 0.321 |
| (%) | (100) | (0) | (14) | (12) | (5) | — | — |
| Pneumonitis | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| (%) | (0) | (0) | (0) | (0) | (0) | — | — |
*Indicates significant difference. Statistic analyses were performed between “*28/−, *28/*6” versus “−/−”, and “*6/*6, *28/*6, *6/−” versus “−/−.” UGT1A1, uridine 5'‐diphospho‐glucuronosyltransferase 1A1.