Table 3.
Thymidylate synthase expression in different clinicopathological features
| Variables | TS positive | χ2 | P |
|---|---|---|---|
| Total | |||
| Age group | |||
| ≤ 45 years | 50.0 | 4.129 | 0.127 |
| 46–69 years | 31.8 | — | — |
| ≥ 70 years | 15.0 | — | — |
| Gender | |||
| Male | 30.1 | 0.025 | 0.875 |
| Female | 31.8 | — | — |
| Histology types | |||
| ADC | 25.0 | 1.328 | 0.515 |
| SCC | 33.3 | — | — |
| Other types | 40.0 | — | — |
| Tumor differentiation | |||
| Poorly differentiated | 40.8 | 4.346 | 0.037 |
| Moderately and well differentiated | 22.7 | — | — |
| TNM stage | |||
| Stage I | 32.0 | 0.431 | 0.806 |
| Stage II | 32.4 | — | — |
| Stage III | 25.8 | — | — |
| Nodal status | |||
| No | 29.7 | 0.049 | 0.825 |
| N1 and N2 | 31.7 | — | — |
| Smoking status | |||
| Smoker | 30.1 | 0.008 | 0.927 |
| Nonsmoker | 31.0 | — | — |
ADC, adenocarcinoma, SCC, squamous cell carcinoma; TNM, tumor‐node‐metastasis; TS, thymidylate synthase.