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. 2016 Jun 24;7:11676. doi: 10.1038/ncomms11676

Figure 3. Scope of alkanes substrates.

Figure 3

Reaction conditions A: 1 (4.0 ml), 2a (0.50 mmol), Cu(OTf)2 (7.5 mol%), Ni(acac)2 (7.5 mol%), AgOAc (10 mol%), dppb (7.5 mol%) and DTBP (2.0 mmol), PhCl (3.0 ml), 130 °C, 3 h. The ratio of regioisomers shown in parentheses was determined by GC–MS. Reaction conditions B: 1 (7.0 ml), 2a (0.50 mmol), Cu(OTf)2 (10 mol%), Ni(acac)2 (10 mol%), AgOAc (5 mol%), dppb (10 mol%) and DTBP (0.75 mmol), 130 °C, 3 h. †DTBP (1.5 mmol) was used. ‡Yields of all regioisomers.