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Combination index (CI) at ED70, ED75, and ED90 values with drug combination on inhibiting [Ca2+]i response to agonists. The CI values at Fa value of 0.70, 0.75, and 0.90 for isobolograms (Figure 3) were calculated with the Calcusyn version 2.1 software.
| ED70 | ED75 | ED90 | ||
|---|---|---|---|---|
| WS-12 | FA : lig (8.3 : 7.8) | 0.16218 | 0.16971 | 0.22336 |
| ASP 7663 | FA : lig (9.1 : 6.8) | 0.26528 | 0.2655 | 0.2848 |
