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Combination index (CI) at ED70, ED75, and ED90 values with drug combination on inhibiting cold-induced upregulation of TRPM8 expression. The CI values at Fa value of 0.70, 0.75, and 0.90 for isobolograms (Figure 5(c)) were calculated.
| Drug (ratio) | CI values at | ||
|---|---|---|---|
| ED70 | ED75 | ED90 | |
| FA : lig (3.416 : 2.325) | 0.14943 | 0.16879 | 0.28823 |
