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. 2016 Jun 20;2016:9605253. doi: 10.1155/2016/9605253

Figure 4.

Figure 4

Inhibition of ATP synthase with oligomycin decreased cytotoxicity in NK cells and IL-2-activated NK cells. Human NK cells were incubated in culture for 72 h in the presence of 50 IU/mL (control) or 2000 IU/mL to induce LAK activity. When indicated, cells were pretreated with 5 μM oligomycin for 30 min. Cytotoxic activity was measured in a 4 h 51Cr release assay using Daudi cells as target cells and a 1 : 1 effector : target ratio. Results are mean ± SE from at least 7 independent experiments (∗∗ p < 0.01; ∗∗∗ p < 0.001).