Table 2. List of potential cigarette smoke-mediated deregulated miRNAs in lung cancer.

microRNA	Direction of expression	Target	Reference
let-7a, b, c, f	Down-regulated	RAS, CDK6, cyclin A2	(49)
miR-10a	Down-regulated	RhoC, HOXD10	(49)
miR-24	Down-regulated	E2F2, MYC, CDC2, DK4, FEN1, XIAP	(86)
miR-26a	Down-regulated	RAS, ERBB2, EGF, TGF	(49,50)
miR-30a	Down-regulated	EFG, NF-κB inhibitors, CDC40	(49)
miR-30c	Down-regulated	RAS, ERBB2, EFG, NF-κB inhibitors, CDC41	(49,50)
miR-31	Down-regulated	RhoA, LATS2, PPP2R2A, RDX	(86)
miR-34 a, b, c	Down-regulated	CDK4, CDK6, cyclin E2, and E2F3	(51)
miR-96	Down-regulated	FOXO1	(86)
miR-99b	Down-regulated	mTOR/FGFR3	(51)
miR-106	Down-regulated	p21, p73	(86)
miR-124a	Down-regulated	heme-oxygenase 1; RAS, ERBB2, EGF, and TGF expression	(49,50)
miR-125a	Down-regulated	ERBB7 (gene for EGFR), IGFR	(52)
miR-130	Down-regulated	GAX, HOXA5	(86)
miR-138	Down-regulated	MYC activation, P53 suppression	(86)
miR-140	Down-regulated	TGF expression, p53 pathway	(49,50)
miR-145	Down-regulated	TNFSF10, EGFR, IGF-1R	(49)
miR-146	Down-regulated	NF-κB activation	(86)
miR-155	Down-regulated	TP53INP1, p21, SMAD1, SMAD5	(86)
miR-191	Down-regulated	HIF1a	(86)
miR-192	Down-regulated	RAS, ERBB2, EGF, and TGF expression	(49,50)
miR-210	Down-regulated	ISCU, NDUFA4, SDHD, COX10, EFNA3, MNT, HIF1a	(86)
miR-218	Down-regulated	SLIT2/3, KIT, RET, BCL9, DCUN1D1, and PDGFRA	(56)
miR-219	Down-regulated	ELK1, FOS activation	(49)
miR-221	Down-regulated	p27 (CDKN1B), p57 (CDKN1C), PUMA	(86)
miR-222	Down-regulated	p27 (CDKN1B), p57 (CDKN1C), PUMA	(86)
miR-223	Down-regulated	RAS pathway	(86)
miR-341	Down-regulated	RAS pathway	(50)
miR-345	Down-regulated	RAS pathway	(51)
miR-431	Down-regulated	RAS, ERBB2, EGF, and TGF expression	(50)
miR-421	Down-regulated	E2B	(51)
miR-450b	Down-regulated	Ki-RAS2, RAB10	(51)
miR-466	Down-regulated	Apoptosis inhibitor 5	(51)
miR-469	Down-regulated	SMAD family member 2	(51)
miR-294	Up-regulated	Zinc finger protein 697, AT-rich interactive domain 4A	(51)