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. 2016 Jun 15;8(6):2716–2726.

Figure 3.

Figure 3

CTGF is a direct target of miR-143. A. The putative binding sites of miR-143 on the CTGF 3’-UTR region (positions 53-59). B. Luciferase activities were determined in SKOV3 48 h after co-transfected with wide-type or mutant-type CTGF 3’-UTR luciferase plasmid and miR-143 or miR-NC. *P < 0.05 compared to miR-NC transfected cells. C. Levels of CTGF mRNA were determined by qRT-PCR in SKOV3 cells transfected with miR-143 mimic or miR-NC. **P < 0.01 compared to miR-NC transfected cells. D. Levels of CTGF protein was determined by Western blot in cells transfected with miR-143 mimic or miR-NC. E. Levels of CTGF mRNA was determined by qRT-PCR in 40 EOC tissues and in 20 normal epithelial tissues. **P < 0.01 compared to normal epithelial tissues. F. The correlation of the expression levels of CTGF and miR-143 in 40 EOC tissue samples.