Table 1.

Determination of IC50 and resistance index of different anticancer drugs (mean ± SD)

A
	IC50		RI	IC50		RI
	SMMC7721	SMMC7721/ADM		SMMC7721	SMMC7721/ADM/MRP1 siRNA
Adriamycin (mg/L)	0.0106±0.004	0.2657±0.003	25.43	0.0106±0.004	0.0608±0.033	5.73
Fluorouracil (mg/L)	0.1263±0.003	3.6129±0.045	28.60	0.1263±0.003	2.0031±0.004	15.86
Vincristine (mg/L)	0.0045±0.002	0.1763±0.008	39.17	0.0045±0.002	0.0112±0.002	2.49
Oxaliplatin (mg/L)	0.0063±0.004	0.1134±0.005	18.30	0.0063±0.004	0.0116±0.002	1.84
B
	IC50		RI	IC50		RI
	SMMC7721	SMMC7721/ADM		SMMC7721	SMMC7721/ADM/MRP2 siRNA
Adriamycin (mg/L)	0.0106±0.004	0.2657±0.003	25.43	0.0106±0.004	0.1023±0.006	9.65
Fluorouracil (mg/L)	0.1263±0.003	3.6129±0.045	28.60	0.1263±0.003	1.4417±0.023	11.41
Vincristine (mg/L)	0.0045±0.002	0.1763±0.008	39.17	0.0045±0.002	0.0452±0.010	10.04
Oxaliplatin (mg/L)	0.0063±0.004	0.1134±0.005	18.30	0.0063±0.004	0.0268±0.005	4.25
C
	IC50		RI	IC50		RI
	SMMC7721	SMMC7721/ADM		SMMC7721	SMMC7721/ADM/MRP3 siRNA
Adriamycin (mg/L)	0.0106±0.004	0.2657±0.003	25.43	0.0106±0.004	0.0521±0.009	4.92
Fluorouracil (mg/L)	0.1263±0.003	3.6129±0.045	28.60	0.1263±0.003	1.2740±0.018	10.09
Vincristine (mg/L)	0.0045±0.002	0.1763±0.008	39.17	0.0045±0.002	0.0146±0.002	3.24
Oxaliplatin (mg/L)	0.0063±0.004	0.1134±0.005	18.30	0.0063±0.004	0.0311±0.002	4.94
D
	IC50		RI	IC50		RI
	SMMC7721	SMMC7721/ADM		SMMC7721	SMMC7721/ADM/MRP4 siRNA
Adriamycin (mg/L)	0.0106±0.004	0.2657±0.003	25.43	0.0106±0.004	0.1052±0.004	9.92
Fluorouracil (mg/L)	0.1263±0.003	3.6129±0.045	28.60	0.1263±0.003	2.9576±0.006	23.41
Vincristine (mg/L)	0.0045±0.002	0.1763±0.008	39.17	0.0045±0.002	0.0532±0.001	11.82
Oxaliplatin (mg/L)	0.0063±0.004	0.1134±0.005	18.30	0.0063±0.004	0.0071±0.002	1.13