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Lipid A modifications occurring in P. aeruginosa during adaptation to long-term chronic infection. The basic tetra-acylated lipid A structure can be modified by: deacylation by PagL; palmitoylation by PagP; acylation by HtrB; acylation by LpxO; addition of Arap4N by PmrAB on position 1 or 4′; and addition of phosphoethanolamine by ColRS on position 1 or 4′.
