Figure 4. Simulating the effects of Delta molecule dynamics on the bias.
(a) No bias in the fate decision-making with no initial polarized localization of Delta particles, despite the asymmetrical shape. Simulation results with three asymmetrical (Along=0.052, 0.063 and 0.092) shapes are shown. (b) Diffusion rate-dependent bias in the fate decision-making of the in silico cells of asymmetrical shapes. Higher diffusion rate: four lattice site length per mcs. Simulation results with three asymmetrical (Along=0.052, 0.063 and 0.092) shapes are shown. (c) Weaker and stronger biases in the fate decision-making with fewer (0.0025 particle concentration (conc.)/diffusion rate) or more Delta particles (0.25 particle conc./diffusion rate), respectively. Simulation results with three asymmetrical (Along=0.052, 0.063 and 0.092) shapes are shown. NS, not significant, *P<0.05; **P<0.01 (χ2-test).