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. 2016 Jun 29;7:12090. doi: 10.1038/ncomms12090

Figure 6. Schematic model of early co-transcriptional events in eukaryotic ribosome biogenesis.

Figure 6

(a) RNA polymerase I (pink) synthesizes the 5′ ETS (dark red), which is co-transcriptionally captured by several subunits of UtpA (shades of green). (b) More subunits of UtpA and Utp18 of UtpB (shades of blue) bind to the 5′ ETS. The U3 snoRNP (orange) is recruited to UtpA and UtpB. (c) The U3 snoRNP (orange) is base-paired at the 3′ hinge with the 5′ ETS and in close proximity to Utp1. (d) Transcription continues and more parts of the 18S rRNA (dark grey) is generated. (e) The completion of the SSU processome with a largely folded 18S enables Utp13 to bind in the vicinity of the 3′ end of the 18S rRNA.