Table 3.

Subjective Ratings of the Severity of Symptoms on the Treatment Emergent Symptom Scale During 12 Weeks of Antipsychotic Treatment

	Baseline (mean ± SD)	4 Weeks (mean ± SD)	8 Weeks (mean ± SD)	12 Weeks (mean ± SD)	Change week 0–4; p	Change week 0–8; p	Change week 0–12; p
Agitation	0.18 ± 0.57	0.13 ± 0.49	0.09 ± 0.39	0.08 ± 0.32
Aripiprazole	0.26 ± 0.64	0.17 ± 0.57	0.12 ± 0.41	0.12 ± 0.41	0.50	0.15	0.46
Olanzapine	0.22 ± 0.72	0.0 ± 0.0	0.0 ± 0.0	0.0 ± 0.0	0.08	0.16	0.08
Quetiapine	0.14 ± 0.54	0.19 ± 0.47	0.26 ± 0.76	0.18 ± 0.48	0.51	0.65	0.45
Risperidone	0.16 ± 0.49	0.14 ± 0.56	0.065 ± 0.29	0.071 ± 0.29	0.52	0.08	0.09
Chi-square p-value	0.60	0.23	0.12	0.41
Restlessness	0.58 ± 0.94	0.28 ± 0.68	0.21 ± 0.59	0.24 ± 0.61
Aripiprazole	0.49 ± 0.85	0.39 ± 0.87	0.29 ± 0.68	0.32 ± 0.64	0.28	0.17	0.36
Olanzapine	0.65 ± 0.98	0.17 ± 0.49	0.14 ± 0.49	0.18 ± 0.65	0.001	0.05	0.09
Quetiapine	0.64 ± 0.93	0.25 ± 0.57	0.26 ± 0.66	0.25 ± 0.65	0.001	0.006	0.01
Risperidone	0.57 ± 0.95	0.29 ± 0.69	0.19 ± 0.58	0.23 ± 0.57	0.005	0.0001	0.0005
Chi-square p-value	0.87	0.81	0.92	0.24
Psychomotor Activation	0.30 ± 0.66	0.20 ± 0.50	0.21 ± 0.57	0.26 ± 0.63
Aripiprazole	0.38 ± 0.70	0.22 ± 0.54	0.24 ± 0.55	0.26 ± 0.61	0.031	0.06	0.18
Olanzapine	0.19 ± 0.55	0.070 ± 0.34	0.14 ± 0.49	0.18 ± 0.61	0.26	0.97	0.68
Quetiapine	0.19 ± 0.47	0.25 ± 0.57	0.27 ± 0.67	0.29 ± 0.66	0.96	0.96	0.63
Risperidone	0.33 ± 0.71	0.23 ± 0.51	0.21 ± 0.58	0.28 ± 0.64	0.14	0.09	0.66
Chi-square p-value	0.67	0.46	0.83	0.55
Insomnia	0.53 ± 0.92	0.12 ± 0.47	0.11 ± 0.46	0.13 ± 0.45
Aripiprazole	0.50 ± 0.82	0.17 ± 0.70	0.12 ± 0.54	0.029 ± 0.17	0.02	0.07	0.0011
Olanzapine	0.55 ± 0.97	0.093 ± 0.48	0.14 ± 0.54	0.11 ± 0.39	0.005	0.023	0.050
Quetiapine	0.53 ± 0.91	0.094 ± 0.39	0.077 ± 0.39	0.069 ± 0.26	0.008	0.017	0.003
Risperidone	0.54 ± 0.94	0.13 ± 0.40	0.096 ± 0.42	0.19 ± 0.56	<0.0001	<0.0001	0.0001
Chi-square p-value	1.00	0.89	0.95	0.25
Malaise	0.37 ± 0.75	0.42 ± 0.76	0.30 ± 0.67	0.24 ± 0.62
Aripiprazole	0.18 ± 0.51	0.36 ± 0.64	0.26 ± 0.57	0.41 ± 0.86	0.04	0.48	0.14
Olanzapine	0.27 ± 0.63	0.49 ± 0.91	0.23 ± 0.55	0.13 ± 0.34	0.17	0.68	0.45
Quetiapine	0.44 ± 0.81	0.28 ± 0.68	0.15 ± 0.46	0.32 ± 0.77	0.48	0.093	0.48
Risperidone	0.43 ± 0.82	0.44 ± 0.75	0.39 ± 0.78	0.20 ± 0.56	0.72	0.17	0.007
Chi-square p-value	0.73	0.11	0.75	0.57
Drowsiness	0.68 ± 0.91	1.2 ± 0.95	1.0 ± 0.97	1.0 ± 0.94
Aripiprazole	0.88 ± 0.88	1.2 ± 0.86	1.2 ± 1.0	1.0 ± 0.94	0.074	0.20	0.32
Olanzapine	0.48 ± 0.67	1.1 ± 0.95	1.3 ± 1.1	1.2 ± 0.93	0.0004	0.0004	0.0001
Quetiapine	0.81 ± 0.92	1.2 ± 1.00	0.7 ± 0.75	0.83 ± 1.0	0.09	0.50	0.71
Risperidone	0.66 ± 0.97	1.2 ± 0.96	0.91 ± 0.95	0.97 ± 0.93	<0.0001	0.07	0.005
Chi-square p-value	0.13	0.78	0.19	0.31
Psychomotor Retardation	0.34 ± 0.83	0.38 ± 0.89	0.32 ± 0.82	0.37 ± 0.85
Aripiprazole	0.55 ± 1.1	0.61 ± 1.1	0.44 ± 0.99	0.63 ± 1.1	0.34	0.55	0.93
Olanzapine	0.24 ± 0.76	0.63 ± 1.1	0.39 ± 0.90	0.47 ± 0.95	0.026	0.17	0.17
Quetiapine	0.33 ± 0.76	0.25 ± 0.67	0.0 ± 0.0	0.21 ± 0.63	0.33	0.16	0.57
Risperidone	0.30 ± 0.79	0.26 ± 0.77	0.34 ± 0.84	0.28 ± 0.76	0.35	0.35	0.78
Chi-square p-value	0.24	0.12	0.42	0.28
Hypersomnia	0.13 ± 0.48	0.92 ± 0.57	0.61 ± 0.92	0.54 ± 0.90
Aripiprazole	0.050 ± 0.22	0.50 ± 0.77	0.74 ± 0.93	0.49 ± 0.85	0.0049	0.0009	0.015
Olanzapine	0.12 ± 0.40	0.79 ± 1.2	0.81 ± 1.1	0.84 ± 1.2	0.0025	0.0052	0.008
Quetiapine	0.14 ± 0.49	0.66 ± 0.94	0.54 ± 0.90	0.41 ± 0.73	0.0011	0.019	0.006
Risperidone	0.16 ± 0.56	0.48 ± 0.84	0.50 ± 0.84	0.48 ± 0.84	<0.0001	0.0001	0.005
Chi-square p-value	0.73	0.02	0.32	0.11

Bolded p-values: <0.05.

SD, standard deviation.