Table 4.

Dose–Side Effect Interactions: Median (25th, 75th Percentile) Doses of Risperidone by Absence (Treatment Emergent Side Effect Scale 0) or Presence of Specific Side Effect (Treatment Emergent Symptom Scale Score 1–3)

		Week 4				Week 8				Week 12
Symptom	Rated	25th%, mg	Median dose, mg	75th%, mg	p	25th%, mg	Median dose, mg	75th%, mg	p	25th%, mg	Median dose, mg	75th%, mg	p
Agitation	No	0.75	12	2	0.12	0.75	1	2	0.38	1	1.5	2	0.66
	Yes	0.40	0.75	1.75		0.63	1	1.5		0.43	1.25	3.25
Restlessness	No	0.75	1.5	2.38	0.029	0.84	1	2	0.005	1	1.75	2.5	0.031
	Yes	0.5	0.75	1.88		0.5	0.75	1		0.61	1	1.5
PM activation	No	0.75	1.5	2.88	0.019	0.94	1	2	0.007	1	1.5	2.5	0.017
	Yes	0.60	1	1.13		0.5	0.5	1		0.62	1	1.5
Insomnia	No	0.75	1	2	0.315	0.75	1	2	0.86	0.75	1.5	2	0.34
	Yes	1	2	3		0.5	0.94	5.25		1.25	1.66	2.88
Drowsiness	No	0.5	0.88	2	0.012	0.60	1	1.5	0.03	0.75	1	2	0.38
	Yes	1	1.5	2.5		1	1.5	2.38		1	1.5	2
PM retardation	No	0.63	1	2	0.008	0.66	1	2	0.03	0.75	1	2	0.002
	Yes	1.88	3	4.5		1	2	4.5		1	3	4.5
Malaise	No	0.63	1	2	0.039	0.5	1	2	0.64	0.82	1.5	2.38	0.81
	Yes	1	2	3		1	1	2		0.88	1.5	2.5
Hypersomnia	No	0.5	1	2	0.032	0.75	1	2	0.43	0.88	1.5	2.25	0.86
	Yes	1	2	3		0.69	1.5	2.25		0.82	1.5	2

Bolded p-values: <0.05.

PM, psychomotor.