Table 2. Association of miR-21, miR-372 and E2F1with PFS in univariate and multivariable analyses.

	N	Progression or death	Median PFS (months)	P-value	HR and 95% CI	P-value	HR and 95% CI
miR-21				0.009		0.01
⩽0.10	41	20	26		1.00 (reference)		1.00 (reference)
>0.10	39	23	8		1.97 (1.18, 3.30)		2.01 (1.17, 3.45)
miR-372				0.03		0.05
⩽1.02	40	17	24		1.00 (reference)		1.00 (reference)
>1.02	40	26	8		1.73 (1.04, 2.89)		1.70 (1.00, 2.89)
E2F1				0.01		0.01
⩽−1.72	42	19	16		1.00 (reference)		1.00 (reference)
>−1.72	38	24	8		1.96 (1.18, 3.27)		1.95 (1.14, 3.33)

Abbreviations: CI=confidence interval; HR=hazard ratio; PFS=progression-free survival.