Table 2. Association of miR-21, miR-372 and E2F1with PFS in univariate and multivariable analyses.
N | Progression or death | Median PFS (months) | P-value | HR and 95% CI | P-value | HR and 95% CI | |
---|---|---|---|---|---|---|---|
miR-21 | 0.009 | 0.01 | |||||
⩽0.10 | 41 | 20 | 26 | 1.00 (reference) | 1.00 (reference) | ||
>0.10 | 39 | 23 | 8 | 1.97 (1.18, 3.30) | 2.01 (1.17, 3.45) | ||
miR-372 | 0.03 | 0.05 | |||||
⩽1.02 | 40 | 17 | 24 | 1.00 (reference) | 1.00 (reference) | ||
>1.02 | 40 | 26 | 8 | 1.73 (1.04, 2.89) | 1.70 (1.00, 2.89) | ||
E2F1 | 0.01 | 0.01 | |||||
⩽−1.72 | 42 | 19 | 16 | 1.00 (reference) | 1.00 (reference) | ||
>−1.72 | 38 | 24 | 8 | 1.96 (1.18, 3.27) | 1.95 (1.14, 3.33) |
Abbreviations: CI=confidence interval; HR=hazard ratio; PFS=progression-free survival.