Table 2. Risk factors for any metastasis and for any hepatic metastasis.
|
Any metastasis |
Hepatic metastasis |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Univariate analysis |
Multivariate analysis |
Univariate analysis |
Multivariate analysis |
|||||||||
| Validate | HR | 95% CI | P-value | HR | 95% CI | P-value | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Age >75 | 1.36 | 0.91–2.04 | 0.13 | 1.24 | 0.85–1.80 | 0.26 | 1.21 | 0.59–2.50 | 0.60 | 0.89 | 0.40–1.96 | 0.77 |
| Sex | 0.92 | 0.66–1.27 | 0.60 | 0.85 | 0.61–1.17 | 0.31 | 0.95 | 0.50–1.83 | 0.89 | 0.88 | 0.46–1.69 | 0.70 |
| Body mass index >25 | 0.57 | 0.35–0.95 | 0.03 | 1.17 | 0.57–2.40 | 0.68 | ||||||
| AST >35 | 1.83 | 1.07–3.15 | 0.03 | 0.33 | 0.46–2.42 | 0.28 | ||||||
| ALT >35 | 1.62 | 0.97–2.71 | 0.07 | 1.79 | 0.75–4.29 | 0.19 | ||||||
| Platelet count >100 000 | 1.79 | 0.25–12.8 | 0.56 | 0.58 | 0.80–4.24 | 0.59 | ||||||
| CEA >5.0 ng ml−1 | 1.90 | 1.31–2.75 | <0.01 | 1.72 | 0.89–3.33 | 0.11 | ||||||
| Diabetes mellitus | 1.11 | 0.74–1.65 | 0.62 | 1.78 | 0.88–3.59 | 0.11 | ||||||
| Hepatic virus | 1.07 | 0.53–2.19 | 0.84 | 1.09 | 0.26–4.54 | 0.90 | ||||||
| Hepatic fibrosis | 1.76 | 1.05–2.97 | 0.03 | 1.30 | 0.75–2.25 | 0.34 | 2.84 | 1.25–6.44 | 0.01 | 2.87 | 1.17–7.02 | 0.02 |
| Location | ||||||||||||
| Right-sided colon | Ref | — | — | Ref | — | — | ||||||
| Left-sided colon | 0.93 | 0.64–1.35 | 0.71 | 1.05 | 0.52–2.11 | 0.89 | ||||||
| Rectum | 1.37 | 0.92–2.05 | 0.16 | 0.73 | 0.28–1.91 | 0.52 | ||||||
| Vascular invasion | 3.42 | 2.25–5.22 | <0.01 | 1.86 | 1.21–2.87 | <0.01 | 4.43 | 1.72–11.3 | <0.01 | 2.81 | 1.06–7.43 | 0.04 |
| Stage | ||||||||||||
| I | Ref | — | — | Ref | — | — | Ref | — | — | Ref | — | — |
| II | 7.62 | 3.02–19.2 | <0.01 | 7 | 2.75–17.8 | <0.01 | 3.80 | 1.07–13.5 | 0.04 | 2.75 | 0.76–9.98 | 0.13 |
| III | 19.4 | 7.92–47.7 | <0.01 | 17.9 | 7.21–44.7 | <0.01 | 8.02 | 2.41–26.7 | <0.01 | 5.44 | 1.57–18.9 | <0.01 |
| PS 0, 1/2, 3 and 4 | 0.93 | 0.29–2.98 | 0.90 | 0.44 | 0.06–3.18 | 0.41 | ||||||
Abbreviations: ALT=alanine aminotransferase; AST=aspartate aminotransferase; CEA=carcinoembryonic antigen; CI=confidence interval; HR=hazard ratio; PS=performance status; Ref=reference.