Table 2. Associations between prediagnostic fasting serum biomarkers and meningioma by quartile and gender.
| Fasting hazard ratiosa (95% confidence intervals) | |||||
|---|---|---|---|---|---|
|
Glucose | |||||
| Glucose levels in quartiles | <4.6 mmol l−1 | 4.6-<5.0 mmol l−1 | 5.0-<5.5 mmol l−1 | ≥5.5 mmol l−1 | Ptrendb |
| Women | 1.00 (Ref) | 1.10 (0.77-1.57) | 0.74 (0.49-1.12) | 0.44c (0.26-0.74) | 0.0006 |
| Cases, n | 60 | 64 | 37 | 20 | |
| Men | 1.00 (Ref) | 1.62 (0.86-3.06) | 1.47 (0.78-2.79) | 1.54 (0.82-2.89) | 0.24 |
| Cases, n | 14 | 30 | 31 | 40 | |
|
Cholesterol | |||||
| Cholesterol levels in quartiles | <5.1 mmol l−1 | 5.1-<5.8 mmol l−1 | 5.8-<6.5 mmol l−1 | ≥6.5 mmol l−1 | Ptrendb |
| Women | 1.00 (Ref) | 1.11 (0.72-1.70) | 1.19 (0.76-1.86) | 0.85 (0.53-1.37) | 0.59 |
| Cases, n | 40 | 48 | 49 | 44 | |
| Men | 1.00 (Ref) | 1.15 (0.70-1.90) | 0.63 (0.35-1.13) | 0.70 (0.40-1.21) | 0.06 |
| Cases, n | 29 | 37 | 21 | 28 | |
| Total | 1.00 (Ref) | 1.13 (0.81-1.56) | 0.93 (0.66-1.33) | 0.76 (0.53-1.09) | 0.08 |
| Cases, n | 69 | 85 | 70 | 72 | |
a
Hazard ratios adjusted for age and date of laboratory test, triglycerides and other biomarkers in table.
b
Polynomial linear trend test.
c
A hazard ratio of 0.44 indicates that women with serum glucose levels of at least 5.5 mmol l−1 have meningioma hazard rates 56% lower than do women with serum glucose levels <4.6 mmol l−1.