Table 2. Characteristics of patients with recurrent colorectal cancer according to microsatellite instability status.
| All patients (n=394) | MSI-H (n=20) | MSI-L/MSS (n=374) | P-value | |
|---|---|---|---|---|
|
Age, years | ||||
| Median | 62 | 49 | 63 | 0.001 |
| Range | 14–86 | 14–72 | 28–86 | |
|
Sex | ||||
| Male | 240 (60.9%) | 13 (65.0%) | 227 (60.7%) | 0.816 |
| Female | 154 (39.1%) | 7 (35.0%) | 147 (39.3%) | |
|
Location | ||||
| Right colon | 87 (22.1%) | 10 (50.0%) | 77 (20.6%) | 0.004 |
| Left colon | 134 (34.0%) | 7 (35.0%) | 127 (34.0%) | |
| Rectum | 173 (43.9%) | 3 (15.0%) | 170 (45.5%) | |
|
Stage | ||||
| I | 21 (5.3%) | 1 (5.0%) | 20 (5.3%) | 1 |
| II | 108 (27.4%) | 5 (25.0%) | 103 (27.5%) | |
| III | 265 (67.3%) | 14 (70.0%) | 251 (67.1%) | |
|
Lymphovascular invasion | ||||
| Yes | 172 (43.7%) | 12 (60.0%) | 160 (42.8%) | 0.166 |
| No | 222 (56.3%) | 8 (40.0%) | 214 (57.2%) | |
|
Perineural invasion | ||||
| Yes | 32 (8.1%) | 0 (0.0%) | 32 (8.6%) | 0.391 |
| No | 362 (91.9%) | 20 (100.0%) | 342(91.4%) | |
|
Retrieved lymph nodes | ||||
| ⩾12 | 298 (75.6%) | 17 (85.0%) | 281 (75.1%) | 0.427 |
| <12 | 96 (24.4%) | 3 (15.0%) | 93 (24.9%) | |
|
Differentiation | ||||
| Well differentiated | 64 (16.2%) | 3 (15.0%) | 61 (16.3%) | 0.038 |
| Moderately differentiated | 296 (75.1%) | 12 (60.0%) | 284 (75.9%) | |
| Poorly differentiated | 20 (5.1%) | 3 (15.0%) | 17 (4.5%) | |
| Mucinous carcinoma | 14 (3.6%) | 2 (10.0%) | 12 (3.2%) | |
|
Adjuvant chemotherapy | ||||
| None | 64 (16.2%) | 3 (15.0%) | 61 (16.3%) | 0.46 |
| 5-FU monotherapy | 165 (41.9%) | 6 (30.0%) | 159 (42.5%) | |
| 5-FU/oxaliplatin | 165 (41.9%) | 11 (55.0%) | 154 (41.2%) | |
Abbreviations: MSI-H=high-frequency microsatellite instability; MSI-L/MSS=low-frequency microsatellite instability/microsatellite stability; 5-FU=5-fluorouracil.