Table 2. Univariate and multivariate analyses of overall survival by Cox's proportional hazard model.

		Univariate analysis			Multivariate analysis
Variables	n	HR	95% CI	P-value	HR	95% CI	P-value
Gender (male/female)	155/20	1.64	0.85–3.69	0.151
Age (<65/⩾65)	84/91	1.59	1.04–2.44	0.0309	1.61	1.00–2.63	0.0487
pT stage (T1, 2/T3, 4)	79/96	2.72	1.72–4.44	0.0001	1.96	1.13–3.47	0.0153
pN stage (N0/N1–3)	61/114	2.45	1.51–4.20	0.0002	1.63	0.90–3.09	0.107
pM stage (M0/M1)	28/147	4.62	2.85–7.30	<0.0001	3.61	2.04–6.21	<0.0001
Lymphatic invasion (negative/positive)	40/135	1.62	0.96–2.94	0.0720	1.22	0.61–2.32	0.553
Vessel invasion (negative/positive)	104/71	1.88	1.23–2.86	0.0035	1.34	0.80–2.22	0.261
Tissue type (grade 1, 2/3, 4)	43/132	1.19	0.52–1.39	0.490
Tumour location (Ut, Mt/Lt, Ae)	113/62	1.46	0.94–2.23	0.917
GPC1 expression (low/high)	99/76	3.12	1.96–5.10	<0.0001	3.08	1.91–5.11	<0.0001

Abbreviations: CI=confidence interval; HR=hazard ratio.