Figure 6. 13-LOX activities in wounded Arabidopsis leaves. (a) 13-LOXs interact through jasmonate production. 1. LOX6 participates in the production of jasmonate that upregulates LOX2 expression (from Figure 2). 2. LOX6 and LOX2 together produce jasmonates that enhance LOX3 and LOX4 expression (from Figure 2). 3. Still hypothetical, LOX3 and LOX4 may enhance each other’s expression through jasmonate production; (b) 13-LOX roles in the wound response. Preformed LOX2 rapidly produces arabidopsides, secondary compounds implicated in direct defense [17]. LOX6 and LOX2 produce jasmonates necessary for early gene expression (e.g., JAZ10; 9,15 and LOX3/4 expression; Figure 2 and Figure 4). LOX3 and LOX4 produce jasmonates that ensure correct late-phase VSP2 gene expression (from Figure 3 and Figure 4). Proteins, black; transcripts, blue.