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Methods of crossing the blood-brain barrier: (a) chemical methods and (b) a physical method (e.g., ultrasound). The chemical methods are separated into five different groups RMT (receptor-mediated transcytosis), AMT (adsorptive-mediated transcytosis), BRCP (bovine retinal capillary pericytes), and MRP (multidrug resistance protein). The physical methods rely on the effect of solid particles or electromagnetic/mechanical waves on endothelial cells.
