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. 2016 Apr 13;6(2):13. doi: 10.3390/brainsci6020013

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Perineuronal net (PNN) expression in the primary auditory cortex (A1) of vesicular gamma-amino butyric acid transporter (VGAT)-Venus C57BL/6 mice: (A) VGAT-Venus positive cell bodies and fibers (green) are found throughout all layers of the auditory cortex; (B) wisteria floribunda agglutinin (WFA)-labeled perineuronal nets (PNNs) were found scattered throughout the auditory cortex (A1), but were particularly dense in layer 4; and (C–D) these PNNs often surrounded the VGAT-Venus positive cell bodies, and appeared to be more highly expressed in the rostral portions of the primary auditory cortex. Panel D is magnified from boxed region in Panel C. A1, primary auditory cortex; Hip, hippocampus; 1–6, cortical layers 1–6.