Table 2.
EAE disease.
| EAE | Females | Males | ||
|---|---|---|---|---|
| Ast-IL-6 KO | Floxed | Ast-IL-6 KO | Floxed | |
| Incidence | 21/23 | 28/28 | 11/11 | 17/18 |
| Mortality | 3/23 | 0/28 | 0/11 | 0/18 |
| Day of onset | 13.38 ± 0.59 * | 11.57 ± 0.29 | 12.27 ± 0.52 * | 11.65 ± 0.49 |
Results shown are pooled data from Experiments 1–3 separated by sex and genotype. For each animal, time to disease onset was defined by a clinical score ≥1. For statistical analysis, a two-way ANOVA for genotype (floxed vs. Ast-IL-6 KO mice) and sex as the main factors was performed. * p < 0.05 vs. floxed mice.